Evidence-based Clinical Practice Guidelines for

Acute Nontraumatic RLQ Abdominal Pain and Tenderness and

Acute Appendicitis

 

Clinical Issue/Question
 

What do we do when we encounter a grossly normal appendix when we operate with a diagnosis of acute appendicitis?

 

Format of Guidelines Development

 

 

 

Clinical Scenario and Issue

 

In a non-immunocompromised patient of any age, any gender, communicative, coherent, with stable vital signs with acute nontraumatic right lower quadrant abdominal pain and tenderness,

With a primary clinical and preoperative diagnosis of acute appendicitis,

Patient is operated on,

 

What do we do when we encounter a grossly normal appendix when we operate with a diagnosis of acute appendicitis?

 

 

Statement of Premises:

 

Non-immunocompromised patient with preop diagnosis of acute appendicitis.

 

Intraoperative findings:

 

Appendix grossly normal

No peritonitis

No gross abnormality noted in the abdomen

            No definite alternative diagnosis

 

Question: To remove the appendix or not? 

 

 

Operational Definition of Terms in the Issue/Question:

 

Non-immunocompromised patient with preop diagnosis of acute appendicitis.

 

Intraoperative findings:

 

Appendix grossly normal

No peritonitis

No gross abnormality noted in the abdomen

            No definite alternative diagnosis

 

Question: To remove the appendix or not? 

 

 

Evidence Appraisal Plan:

 

End-points in answering the question:

 

            During an operation for acute appendicitis, to remove a grossly normal appendix or not and why.

 

 

Approach in answering the question:

 

            Look for frequency of microscopic appendicitis in grossly normal appendices removed.

 

            Look for data that show consequences of not removing grossly normal appendix.

 

 

 

Search Methodology:

 

Tracking:

            Medline – for international journal publications

            Herdin – for local journal publications

            Internet using various search engines such as AltaVista, Infoseek, Lycos, etc.

 

Retrieval:

 

Retrieval of whole journal article was done through the various libraries of the Metro Manila medical schools, Department of Science and Technology (DOST), and acquaintances.

 

Appraisal (Inclusion Criteria):

 

Appraisal (Inclusion Criteria):

 

·        Papers on finding of normal appendices and what to do with them

·        With data on histopathologic results of the grossly normal and consequences of leaving them behind 

 

 

Search and Tracking Outcome:

 

·        Total no. of papers and abstracts appraised:  3

 

·        Level of evidences: Level III Evidences

 

Tracking and Retrieval Results:

 

Database

Search engine

Search span

Search words

No. of titles

Relevant abstracts/papers

Medline

1966-1999 (August)

 Ap +  laparoscopy

 157

3

Herdin

 

 Appendicitis

      107

 0

AltaVista, Infoseek, Lycos, etc

 

Appendicitis

Tntc

 0

 

 

 

 

 Presentation of Primary Evidences:

 

Authors

Grossly normal appendix

– removed /left behind

N

Microscopic

appendicitis

Operated for the 2nd time for appendicitis

Barrat, 1999

Left behind

 

65

 

5-10% (Removed)

1(1%)

Greason, 1998

Left behind

Removed

28

44

 

2 (5%)

1(3.5%)

Grunewald, 1993

Removed

43

11(26%)

 

See References

 

 

 

Distillation of all available evidences to come out with recommendations or answers to the clinical issue/question:

 

In view of the fact that a grossly normal appendix may have microscopic appendicitis or may be in the early stage of appendicitis in which there is only mucosal involvement (5-26%), removal of the grossly normal appendix is recommended.

 

This will avoid a second operation in case the appendix was not removed and the appendiceal disease process progresses.

 

 

  

 Summary of Answer to Question or Recommendations:

 

In a non-immunocompromised patient of any age, any gender, communicative, coherent, with stable vital signs with acute nontraumatic right lower quadrant abdominal pain and tenderness,

With a primary clinical and preoperative diagnosis of acute appendicitis,

Patient is operated on,

 

What do we do when we encounter a grossly normal appendix when we operate with a diagnosis of acute appendicitis?

 

When we encounter a grossly normal appendix during an operation for acute appendicitis,

 

in the absence of an alternative diagnosis,

 

                        REMOVE THE APPENDIX.

 

In view of the fact that a grossly normal appendix may have microscopic appendicitis or may be in the early stage of appendicitis in which there is only mucosal involvement (5-26%), removal of the grossly normal appendix is recommended.

 

This will avoid a second operation in case the appendix was not removed and the appendiceal disease process progresses.

 

 

 

 

Future Research Issues/Questions Arising from Attempts to Answer Issue:

 

 None at the moment

 

 

 

References:

 

1.       Greason KL, Rappold JF, Liberman MA.

Incidental laparoscopic appendectomy for acute right lower quadrant abdominal pain. Its time has come.  Surg Endosc, 1998 Mar, 12:3, 223-5.

 

2.      Grunewald B, Keating J.

Should the 'normal' appendix be removed at operation for appendicitis?

J R Coll Surg Edinb, 1993 Jun, 38:3, 158-60

 

3.      Barrat C; Catheline JM; Rizk N; Champault GG

Does laparoscopy reduce the incidence of unnecessary appendicectomies?

Surg Laparosc Endosc, 1999 Jan, 9:1, 27-31

 

 

 

Quick Reference Guide or Algorithm:

 

In a non-immunocompromised patient of any age, any gender, communicative, coherent, with stable vital signs with acute nontraumatic right lower quadrant abdominal pain and tenderness,

With a primary clinical and preoperative diagnosis of acute appendicitis,

Patient is operated on,

 

What do we do when we encounter a grossly normal appendix when we operate with a diagnosis of acute appendicitis?

 

When we encounter a grossly normal appendix during an operation for acute appendicitis,

 

in the absence of an alternative diagnosis,

 

                        REMOVE THE APPENDIX.

 

In view of the fact that a grossly normal appendix may have microscopic appendicitis or may be in the early stage of appendicitis in which there is only mucosal involvement (5-26%), removal of the grossly normal appendix is recommended.

 

This will avoid a second operation in case the appendix was not removed and the appendiceal disease process progresses.